Coprecipitation of nonoxynol-9 with polyvinylpyrrolidone to decrease vaginal irritation potential while maintaining spermicidal potency
نویسندگان
چکیده
منابع مشابه
Spermicidal and Contraceptive Potential of Desgalactotigonin: A Prospective Alternative of Nonoxynol-9
Crude decoction of Chenopodium album seed showed spermicidal effect at MIC 2 mg/ml in earlier studies. Systematic isolation, characterization and evaluation revealed that the major metabolite Desgalactotigonin (DGT) is the most effective principle in both in vitro and in vivo studies. The in vitro studies comprises (a) rat and human sperm motility and immobilizing activity by Sander-Cramer assa...
متن کاملPhase I safety & preliminary acceptability of nonoxynol-9 vaginal pessary as a vaginal microbicide in low risk women in Pune, India.
BACKGROUND & OBJECTIVES Though nonoxynol-9 (N-9) is available in India as a spermicidal pessary, data on its safety as a potential microbicide among Indian women are not available. Nonoxynol-9 containing compounds have shown anti-HIV activity in in vitro studies and protection against cervical infections. Nonoxynol-9 is being extensively evaluated as a vaginal microbicide world-wide. We assesse...
متن کاملAre there alternatives to nonoxynol-9 spermicide?
You're certainly not alone in your interest of this method. Spermicide is a popular option for birth control because it is easily accessible, simple to use, and provides added lubrication. Results from recent scientific studies for newer alternatives look promising, but more research is still needed. Some of the new ingredients being studied that may be able to function as spermicide (and provi...
متن کاملThe safety of candidate vaginal microbicides since nonoxynol-9: a systematic review of published studies.
OBJECTIVE To gain a greater understanding of published safety data for candidate vaginal microbicides. DESIGN A systematic review of human safety trials of candidate vaginal microbicides - agents designed to protect women against HIV and other sexually transmitted infections. METHODS Trials were published in peer-reviewed journals, and publication cut-off was August week 4, 2008. Trials of ...
متن کاملSafety of a nonoxynol-9 vaginal gel in Kenyan prostitutes. A randomized clinical trial.
OBJECTIVE To evaluate the safety and toxicity of once-daily administration of Advantage-24 (Columbia Research Laboratories, Inc., Rockville Centre, NY), a vaginal gel containing 52.5 mg of nonoxynol-9 (N-9), including the effects of this gel on the vaginal and cervical epithelium. STUDY DESIGN Randomized, placebo-controlled, double-blind crossover trial, with a 2-week product application peri...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2003
ISSN: 1530-9932
DOI: 10.1208/pt040330